Endocrine Abstracts

The effects of radiotherapy, one of the main options currently available for cancer therapy, depend on various factors, including the dose and the radiosensitivity of tumour cells. Radiotherapy is known to induce apoptosis in breast cancer cells, but the effects of irradiation on components of the intracellular pathways involved in apoptosis and survival are largely unknown. BAD, which is a pro-apoptotic member of the Bcl-2 family plays a central role in the interaction betwee...